Protein Modification Reagents TCEP solution
TCEP is a superior reducing reagent for disulfides. An odorless alternative to DTT.
M116 Tris ( 2-carboxyethyl )phosphine ( neutral solution )
| unit | price |
| 1ml | $20.00 |
| 2ml | $38.00 |
| 5ml | $85.00 |
| 10ml | $150.00 |
| 25ml | $360.00 |
500mM in water
[ 51805-45-9 ] f.w.: 250.1 daltons
-
Reduces organic disulfides to thiols rapidly and quantitatively in water
-
Selective for disulfides, does not react with other functional groups on proteins
-
More complete reductions than dithiothreitol ( DTT ) Cleland's reagent
-
Reagent is odorless, non volatile and stable at room temperature
-
Dilute (1mM) TCEP solutions react rapidly at room temperature
-
Solutions are stable for 1 year at room temp under argon
We manufacture these products so bulk quotations are always available with substantial savings.
Each product is accompanied with a certificate of analysis.
TCEP references:
1. Kirkley, T.L., Anal. Biochem, 180, 231-236 (1989).
2. Andrews, P. C., Dixon, J.E., Anal. Biochem, 161, 524-528 (1987).
3. Schonberg, A., Chem Ber., 163-164 (1935).
4. Rauhut, M., et. al., JACS, 81, 1103-1107 (1959).
5. Chen, C.S., Fujimoto, Y., Girdoukas, G.Sih, C.J., JACS, 109, 6825-6309 (1987).
6. Houk, J., Whitesides, G.M., JACS, 109, 6825-6836 (1987).
7. Grayson, M., Farley, C.E., Chimie Organique du Phophore, Collogues Int'l du Centre Nat'l de la Recherche Scientifique, No. 182 CNRS, Paris, 275-284 (1970).
8. Overman, L.E., O'Conner, E.M., JACS, 98, 771-775 (1977).
9. Rosenfield, R.E., Parthasarthy, R., Dunitis, J.D., JACS, 99, 4860-4862 (1977).